Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells

Company: University of California
Location: San Francisco
Posted on: June 1, 2025

Job Description:

Home > Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem CellsPre-Clinical Research: Engineering CD34+ Hematopoietic Stem CellsLocation: 3739 Balboa Street #1057, San Francisco, CA 94121, United StatesJob Posted Date: July 23, 2024Positions Available: Part-time, Postdoc, VolunteerPopulation: Life SciencesOur organization received funding and is conducting pre-clinical research in transplant medicine, focusing on genetic engineering techniques to improve organ transplant compatibility and reduce rejection. The intention of the pre-clinical trial is to get the results published in a scientific journal and evaluate implementation in transplant recipients.We are specifically studying two potential pathways:

• Deactivation of HLA genes in donor organs using CRISPR-Cas9 delivered via lentiviral vectors or electroporation.
• Creating chimeric bone marrow via engineered CD34+ cells.Job Requirements:Experience/Skills:
• Gene knockout engineering using lentiviral vectors or electroporation and CRISPR-Cas9
• Strong knowledge of the immune system
• Good Laboratory Practice (GLP) standards with animal models
• Research design and scientific investigation backgroundPreferred Experience:
• Understanding of hematopoietic stem cell chimerism
• Familiarity with FDA approval processes
• Post-doctorate or PhDHow to Apply:Send email with resume to Austin@Cardioclone.com
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Keywords: University of California, Watsonville , Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells, Engineering , San Francisco, California